WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: gene_symbol, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=13; E=1.73; R=7.50; rawP=2.37e-08; adjP=2.18e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  STUB1 NA STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 10273 ENSG00000103266
2  HERC2 NA HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 8924 ENSG00000128731
3  TRAF6 NA TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 7189 ENSG00000175104
4  FBXW11 NA FBXW11 F-box and WD repeat domain containing 11 23291 ENSG00000072803
5  CUL5 NA CUL5 cullin 5 8065 ENSG00000166266
6  UBE3A NA UBE3A ubiquitin protein ligase E3A 7337 ENSG00000114062
7  HUWE1 NA HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 10075 ENSG00000086758
8  SIAH1 NA SIAH1 siah E3 ubiquitin protein ligase 1 6477 ENSG00000196470
9  HERC1 NA HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 8925 ENSG00000103657
10  WWP1 NA WWP1 WW domain containing E3 ubiquitin protein ligase 1 11059 ENSG00000123124
11  UBE2G1 NA UBE2G1 ubiquitin-conjugating enzyme E2G 1 7326 ENSG00000132388
12  UBE3B NA UBE3B ubiquitin protein ligase E3B 89910 ENSG00000151148
13  BTRC NA BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 8945 ENSG00000166167


Database:KEGG pathway       Name:RNA transport       ID:03013
C=151; O=11; E=1.94; R=5.67; rawP=4.53e-06; adjP=0.0001
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  GEMIN5 NA GEMIN5 gem (nuclear organelle) associated protein 5 25929 ENSG00000082516
2  SUMO2 NA SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 6613 ENSG00000188612
3  WIBG NA WIBG within bgcn homolog (Drosophila) 84305 ENSG00000170473
4  NUP54 NA NUP54 nucleoporin 54kDa 53371 ENSG00000138750
5  DDX39B NA DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 7919 ENSG00000198563
6  UPF2 NA UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 26019 ENSG00000151461
7  ACIN1 NA ACIN1 apoptotic chromatin condensation inducer 1 22985 ENSG00000100813
8  PHAX NA PHAX phosphorylated adaptor for RNA export 51808 ENSG00000164902
9  NUP85 NA NUP85 nucleoporin 85kDa 79902 ENSG00000125450
10  EIF3A NA EIF3A eukaryotic translation initiation factor 3, subunit A 8661 ENSG00000107581
11  PAIP1 NA PAIP1 poly(A) binding protein interacting protein 1 10605 ENSG00000172239


Database:KEGG pathway       Name:Endocytosis       ID:04144
C=201; O=13; E=2.58; R=5.03; rawP=2.37e-06; adjP=0.0001
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ARFGAP1 NA ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 55738 ENSG00000101199
2  TRAF6 NA TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 7189 ENSG00000175104
3  EPN2 NA EPN2 epsin 2 22905 ENSG00000072134
4  VPS37A NA VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 137492 ENSG00000155975
5  SMAP1 NA SMAP1 small ArfGAP 1 60682 ENSG00000112305
6  IGF1R NA IGF1R insulin-like growth factor 1 receptor 3480 ENSG00000140443
7  DNM1L NA DNM1L dynamin 1-like 10059 ENSG00000087470
8  IQSEC1 NA IQSEC1 IQ motif and Sec7 domain 1 9922 ENSG00000144711
9  WWP1 NA WWP1 WW domain containing E3 ubiquitin protein ligase 1 11059 ENSG00000123124
10  CHMP2B NA CHMP2B charged multivesicular body protein 2B 25978 ENSG00000083937
11  RAB5B NA RAB5B RAB5B, member RAS oncogene family 5869 ENSG00000111540
12  RABEP1 NA RABEP1 rabaptin, RAB GTPase binding effector protein 1 9135 ENSG00000029725
13  GIT2 NA GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 9815 ENSG00000139436


Database:KEGG pathway       Name:mRNA surveillance pathway       ID:03015
C=83; O=6; E=1.07; R=5.63; rawP=0.0007; adjP=0.0147
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  UPF2 NA UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 26019 ENSG00000151461
2  PAPOLG NA PAPOLG poly(A) polymerase gamma 64895 ENSG00000115421
3  ACIN1 NA ACIN1 apoptotic chromatin condensation inducer 1 22985 ENSG00000100813
4  HBS1L NA HBS1L HBS1-like (S. cerevisiae) 10767 ENSG00000112339
5  WIBG NA WIBG within bgcn homolog (Drosophila) 84305 ENSG00000170473
6  DDX39B NA DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 7919 ENSG00000198563


Database:KEGG pathway       Name:Vascular smooth muscle contraction       ID:04270
C=116; O=7; E=1.49; R=4.70; rawP=0.0008; adjP=0.0147
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  PRKCE NA PRKCE protein kinase C, epsilon 5581 ENSG00000171132
2  MYLK3 NA MYLK3 myosin light chain kinase 3 91807 ENSG00000140795
3  ARAF NA ARAF v-raf murine sarcoma 3611 viral oncogene homolog 369 ENSG00000078061
4  GNA11 NA GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2767 ENSG00000088256
5  ARHGEF1 NA ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 9138 ENSG00000076928
6  ADCY9 NA ADCY9 adenylate cyclase 9 115 ENSG00000162104
7  KCNMB3 NA KCNMB3 potassium large conductance calcium-activated channel, subfamily M beta member 3 27094 ENSG00000171121


Database:KEGG pathway       Name:Vasopressin-regulated water reabsorption       ID:04962
C=44; O=4; E=0.57; R=7.08; rawP=0.0024; adjP=0.0315
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  DYNC1H1 NA DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 1778 ENSG00000197102
2  ARHGDIB NA ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 397 ENSG00000111348
3  RAB5B NA RAB5B RAB5B, member RAS oncogene family 5869 ENSG00000111540
4  ADCY9 NA ADCY9 adenylate cyclase 9 115 ENSG00000162104


Database:KEGG pathway       Name:RIG-I-like receptor signaling pathway       ID:04622
C=71; O=5; E=0.91; R=5.48; rawP=0.0022; adjP=0.0315
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  RNF125 NA RNF125 ring finger protein 125, E3 ubiquitin protein ligase 54941 ENSG00000101695
2  ATG12 NA ATG12 autophagy related 12 9140 ENSG00000145782
3  TRAF6 NA TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 7189 ENSG00000175104
4  MAVS NA MAVS mitochondrial antiviral signaling protein 57506 ENSG00000088888
5  MAPK9 NA MAPK9 mitogen-activated protein kinase 9 5601 ENSG00000050748


Database:KEGG pathway       Name:Nicotinate and nicotinamide metabolism       ID:00760
C=24; O=3; E=0.31; R=9.73; rawP=0.0035; adjP=0.0358
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  NADSYN1 NA NADSYN1 NAD synthetase 1 55191 ENSG00000172890
2  CD38 NA CD38 CD38 molecule 952 ENSG00000004468
3  NMNAT1 NA NMNAT1 nicotinamide nucleotide adenylyltransferase 1 64802 ENSG00000173614


Database:KEGG pathway       Name:Wnt signaling pathway       ID:04310
C=150; O=7; E=1.93; R=3.63; rawP=0.0034; adjP=0.0358
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  EP300 NA EP300 E1A binding protein p300 2033 ENSG00000100393
2  CREBBP NA CREBBP CREB binding protein 1387 ENSG00000005339
3  FBXW11 NA FBXW11 F-box and WD repeat domain containing 11 23291 ENSG00000072803
4  NFATC3 NA NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 4775 ENSG00000072736
5  SIAH1 NA SIAH1 siah E3 ubiquitin protein ligase 1 6477 ENSG00000196470
6  BTRC NA BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 8945 ENSG00000166167
7  MAPK9 NA MAPK9 mitogen-activated protein kinase 9 5601 ENSG00000050748


Database:KEGG pathway       Name:Progesterone-mediated oocyte maturation       ID:04914
C=86; O=5; E=1.10; R=4.53; rawP=0.0051; adjP=0.0452
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ARAF NA ARAF v-raf murine sarcoma 3611 viral oncogene homolog 369 ENSG00000078061
2  IGF1R NA IGF1R insulin-like growth factor 1 receptor 3480 ENSG00000140443
3  PDE3B NA PDE3B phosphodiesterase 3B, cGMP-inhibited 5140 ENSG00000152270
4  ADCY9 NA ADCY9 adenylate cyclase 9 115 ENSG00000162104
5  MAPK9 NA MAPK9 mitogen-activated protein kinase 9 5601 ENSG00000050748




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).